Irish government funding will enable 50 additional medical students to study at Queen's University, Belfast.
The first 25 places will be available for students from Ireland or Northern Ireland from September 2024.
A further 25 places will be available from September 2025, bringing the total to 50.
The places will be co-funded by the Irish Department of Health and that of Further and Higher Education, Research, Innovation and Science.
Students who take up the places will pay the same student contribution rate as their counterparts studying in medical schools in the Republic of Ireland and will commit to applying to take up a position in the Irish Health Service Executive (HSE) as an intern at the end of their studies.
It comes after the Irish government announced new funding worth €800m (£685m) for cross-border projects, including the upgrade of the A5.
Irish Minister for Further and Higher Education, Research, Innovation and Science, Simon Harris described the funding as "a really exciting partnership" between the government and Queen's.
He said it recognises "the importance of increasing healthcare graduates across both jurisdictions on the island of Ireland".