Up to 250 jobs are to be axed at the University of Wolverhampton because of a £20m deficit.
A drop in student enrolments, rising inflation and the Covid-19 pandemic had all impacted its ability to reduce the shortfall, it said.
Employees at the university, which has four campuses across the Black Country and Shropshire, will now enter a consultation period.
Bosses are "committed to treating staff with dignity and respect", it said.
The number of at-risk jobs represents more than a tenth of the workforce, with 2,200 employed at the campuses.
