There are plans to ban almost all cars from the road in front of Ulster University's (UU) new Belfast campus for six months.
The Department for Infrastructure (DfI) has launched a consultation on the proposals for part of York Street.
It would mean that only buses, blue badge holders, bicycles and emergency vehicles could use the road.
About 15,000 staff and students are due to begin using the new building at the start of the new term later this month.