A university said it was looking at making compulsory redundancies in order to make savings.
The University of East Anglia (UEA) in Norwich said it was "experiencing significant challenges" with finances.
It said the challenges were "driven by the effects of Covid, the tuition fee freeze, pressures on student numbers and rising costs".
In 2021-22, the university reported a £13.9m loss. It said it was "working closely" with campus trade unions.
Jo Grady, general secretary of the University and College Union, said: "University staff are asked to pay the price.
"Solidarity with our UEA branch - the entire union stands shoulder to shoulder with you in fighting this."r
